| 摘要 |
1,244,961. Thiazole derivatives. WELLCOME FOUNDATION Ltd. (Burroughs Wellcome & Co. U.S.A. Inc.). 18 Sept., 1968 [22 Sept., 1967], No. 43366/67. Heading C2C. Compounds of the general Formula (I) (R<SP>1</SP> = Me or Et; X- = anion; NR 2 = NMe 2 or NEt 2 , Z = Ph or NR 2 = pyrrolidino, Z = H, halogen, Ph, PhO or p-MeOPh) are prepared by (a) reacting a compound of the Formula (II) with a compound of the Formula (III) or (b) reacting a compound of the Formula (VII) (A = nucleophilic atom or group) with a compound of the Formula (VIII) The latter reaction proceeds via an intermediate of the Formula (IX) which may be isolated and ring-closed. The starting materials of Formula (II) are prepared by the following route The compounds (I) are active against nematodes and may be administered in the form of pharmaceutical compositions containing them in association with a carrier. |
