NOVEL QUINUCLIDINE DERIVATIVES HAVING TRICYCLIC FUSED HERETO RING

摘要

Novel quinuclidine derivatives represented by general formula (I) and useful as a cholesterol-lowering agent having a potent activity of inhibiting squalene synthase without any side effect, pharmaceutically acceptable salts thereof, hydrates thereof or solvates thereof. In said formula, R1 represents hydrogen, halogeno or lower alkyl; R2 represents hydrogen, hydroxy or lower alkoxy; --- represents a single bond or a double bond, provided that R2 is absent when --- is a double bond; X and Y are the same or different and each represents a bond, oxygen (-O-), carbonyl (-CO-), -S(O)p- or -NR3-, wherein p is 0, 1 or 2; and R3 represents hydrogen or optionally substituted lower alkyl; and A represents saturated or unsaturated lower alkylene, -(CH2)mZ(CH2)n- or -(CH2)mZ(CH2)nCR4=, wherein Z represents oxygen (-O-), -S(O)q-, carbonyl (-CO-) or -NR5-; R4 represents hydrogen, halogeno or lower alkyl; R5 represents hydrogen or lower alkyl; m and n are the same or different and each represents an integer of 1 to 5, provided that m + n is an integer of 1 to 5; and q is 0, 1 or 2, provided that when one of X and Y is a bond, then A represents -(CH2)mZ(CH2)nCR4=.