IMMUNIZATION AGAINST NEISSERIA GONORRHOEAE AND NEISSERIA MENINGITIDIS

摘要

The present invention relates to a method of immunization against infection by a pathogenic Neisseria species. The method employs parenteral priming using a priming antigen, followed by oral immunization with gamma-irradiated, Protein III-deficient killed whole cells of Neisseria gonorrhoeae strain 340 or parenteral priming using a priming antigen followed by oral immunization with gamma-irradiated class 4 protein-deficient whole cells of Neisseria meningitidis.