发明名称 |
3-[2-(3-ACYLAMINO-2-OXO-2H-PYRIDIN-1-YL)-ACETYLAMINO]-4-OXO-PENTANOIC ACID DERIVATIVES AND THEIR USE AS CASPASE INHIBITORS |
摘要 |
<p>The present invention provides a compound of formula I: wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.</p> |
申请公布号 |
EP1833794(A1) |
申请公布日期 |
2007.09.19 |
申请号 |
EP20050825102 |
申请日期 |
2005.11.21 |
申请人 |
VERTEX PHARMCEUTICALS INCORPORATED |
发明人 |
CHARRIER, JEAN-DAMIEN;KNEGTEL, RONALD;MORTIMORE, MICHAEL;STUDLEY, JOHN, R. |
分类号 |
C07D213/75;A61K31/4412;A61K31/4436;A61K31/4439;C07D401/06;C07D409/06 |
主分类号 |
C07D213/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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