MUTANT P21<CIP1/WAF1> AND CELL GROWTH CONTROL

摘要

Disclosed are methods and compositions regarding separate mutant forms of p21 that are associated with control of cell growth. Substitution of Thr<145> with another amino acid, such as Ala, results in failure to be phosphorylate at that site and leads to retention of the polypeptide in the nucleus, resulting in preferentially suppressing growth of transformed cells. Alternatively, substitution of Thr<145> with another amino acid, such as Asp, results in cytoplasmic translocation of the polypeptide and results in enhancing cellular survival.