发明名称 |
Antigen binding proteins that bind ErbB3 |
摘要 |
There is disclosed compositions and methods relating to or derived from anti-ErbB3 antibodies. More specifically, there is disclosed fully human antibodies that bind ErbB3, ErbB3-binding fragments and derivatives of such antibodies, and ErbB3-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having ErbB3 related disorders or conditions, including various inflammatory disorders and various cancers. |
申请公布号 |
US9346890(B2) |
申请公布日期 |
2016.05.24 |
申请号 |
US201314061548 |
申请日期 |
2013.10.23 |
申请人 |
Sorrento Therapeutics, Inc. |
发明人 |
Gros Edwige;Zhang Yanliang;Zhou Heyue |
分类号 |
A61K39/395;C07K16/40;C07K16/32 |
主分类号 |
A61K39/395 |
代理机构 |
McCarter & English, LLP |
代理人 |
McCarter & English, LLP ;Herritt Danielle L.;Cowles Cristin H. |
主权项 |
1. A recombinant anti-ErbB3 antibody comprising a heavy chain variable domain having an amino acid sequence selected from the group consisting of SEQ ID NO. 3, SEQ ID NO. 5, and SEQ ID NO. 7, and comprising a light chain variable domain having an amino acid sequence selected from the group consisting of SEQ ID NO. 4, SEQ ID NO. 6 and SEQ ID. NO. 8, wherein the antibody is an IgG. |
地址 |
San Diego CA US |