发明名称 |
COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE |
摘要 |
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effective to alleviate conditions associated with a reduced concentration of PEA. Among other uses, various NAAA inhibitors are especially contemplated as therapeutic agents in the treatment of inflammatory diseases. |
申请公布号 |
US2016256432(A1) |
申请公布日期 |
2016.09.08 |
申请号 |
US201615072194 |
申请日期 |
2016.03.16 |
申请人 |
The Regents of the University of California ;Universita Degli Studi Di Urbino "Carlo Bo" ;Universita Degli Studi Di Parma |
发明人 |
Piomelli Daniele;Tarzia Giorgio;Mor Marco;Duranti Andrea;Tontini Andrea |
分类号 |
A61K31/337 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Oakland CA US |