Methods for manipulating phagocytosis mediated by CD47

摘要

Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.

主权项

1. A method of increasing the elimination of hematopoietic cancer cells by phagocytosis in a human subject comprising:
administering to the subject a first monoclonal antibody specific for a marker of the cancer cells other than CD47 which comprises an Fc region capable of engaging Fc receptors on phagocytic cells to signal phagocytosis of the hematopoietic cancer cells, and a second monoclonal antibody that prevents the binding of CD47 to SIRP alpha and increases phagocytosis of the hematopoietic cancer cells by the first antibody.