Methods and uses of a modified cecropin for treating endoparasitic and bacterial infections

摘要

The present disclosure provides a modified cecropin protein comprising a cecropin or a variant thereof fused to a hydrophilic tail lacking a C-terminal glycine. The present disclosure also provides pharmaceutical compositions, methods and uses of the modified cecropin protein or nucleic acid for treating or preventing endoparasites, such as Plasmodium, and bacteria.

主权项

1. A method of inhibiting an organism selected from the group consisting of an endoparasite, a bacterium and a malarial parasite, comprising administering a modified cecropin, wherein the modified cecropin comprises a peptide fused to a hydrophilic tail lacking a C-terminal glycine, peptide is selected from the group consisting of a cecropin, a variant peptide having at least 90% sequence identity with a cecropin, and a variant peptide having at least 95% sequence identity with a cecropin.