HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES

摘要

The invention relates to new humanized monoclonal antibody comprising an artificial modified consensus sequence at least of the FRs of the heavy chain variable region of a human immunoglobulin. The invention relates, furthermore, to corresponding humanized and chimeric monoclonal antibodies which are binding to epitopes of the Epidermal Growth Factor wherein the responsible hypervariable regions have the following amino acid sequence: light chain:CDR-1: -Ser-Ala-Ser-Ser-Ser-Val-Thr-Tyr-Met-Tyr-; CDR-2: -Asp-Thr-Ser-Asn-Leu-Ala-Ser-; CDR-3: -Gln-Gln-Trp-Ser-Ser-His-Ile-Phe-Thr-; heavy chain: CDR-1: -Ser-His-Trp-Met-His-; CDR-2: -Glu-Phe-Asn-Pro-Ser-Asn-Gly-Arg-Thr-Asn-Glu-Lys-Phe-Lys-Ser-; CDR-3: -Arg-Asp-Tyr-Asp-Tyr-Asp-Gly-Arg-Tyr-Phe-Asp-Tyr-. The antibodies can be used for therapeutical and diagnostic purposes.