| 摘要 |
PCT No. PCT/GB89/01345 Sec. 371 Date Jul. 10, 1991 Sec. 102(e) Date Jul. 10, 1991 PCT Filed Nov. 13, 1989 PCT Pub. No. WO90/05143 PCT Pub. Date May 17, 1990.A polypeptide derived from leeches of the species Hirudinaria manillensis has the following amino acid sequence: <IMAGE> <IMAGE> <IMAGE> <IMAGE> <IMAGE> wherein Xaa indicates any amino acid residue; D indicates Cys or Pro; E indicates Glu, Asp or His; F indicates Asp, Lys or Trp; or a pharmaceutically acceptable salt, derivative or bioprecursor thereof. The polypeptide, and fragments thereof, is a specific anti-thrombin useful as a medicament.
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