| 发明名称 | Aptamer against midkine and applications thereof | ||
| 摘要 | The present invention provides an aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I):; wherein X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond, X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, and X3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T. | ||
| 申请公布号 | US9506070(B2) | 申请公布日期 | 2016.11.29 |
| 申请号 | US201314646104 | 申请日期 | 2013.11.21 |
| 申请人 | RIBOMIC INC.;OTSUKA PHARMACEUTICAL CO., LTD. | 发明人 | Miyakawa Shin;Fujiwara Masatoshi;Nakamura Yoshikazu;Kadomatsu Kenji;Mu Ping |
| 分类号 | C07H21/02;C07H21/04;C12N15/115;A61K47/48;A61K31/7088;A61K31/713;A61K31/7105;A61K31/711 | 主分类号 | C07H21/02 |
| 代理机构 | Wenderoth, Lind & Ponack, L.L.P. | 代理人 | Wenderoth, Lind & Ponack, L.L.P. |
| 主权项 | 1. An aptamer binding to midkine having a length of not more than 45 nucleotides and capable of forming a potential secondary structure represented by the formula (I): wherein X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond, X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, and X3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T. | ||
| 地址 | Tokyo JP | ||