| 摘要 |
Arylalkyl propylamide derivs. of formula (I), their enantiomers and diastereoisomers and their salts, are new except for N-Ä3-(4-hydroxy-naphth-1-yl)propylÜacetamide or N-Ä3-(4-benzyloxy-naphth-1-yl)propylÜacetamide. In (I), R1 = H, OH, R6 or OR6; R6 = e.g. opt. substd (cyclo)alkyl, opt. substd cycloalkylalkyl, alkenyl, alkynyl, cycloalkenyl, opt. substd phenyl etc.; R1' = R6', OR6', OH, COR7, CH2R7 or OCOR7; R6' = as R6; R7 = opt. substd 1-5C alkyl, opt. substd cycloalkyl or opt. substd cycloalkyl-(1-5C) alkyl, opt. substd phenyl etc.; Het A = e.g. dihydro- or tetrahydronaphthalene, naphthalene, benzothiophene etc.; n = 3-6; R2 = H or alkyl; R3 = C(=X)-R4 or C(=X)-NH-R5; X, X' = O or S; R4 = e.g. H, opt. substd. alkyl, alkenyl, alkynyl, opt. substd. cycloalkyl or opt. substd. cycloalkylalkyl; and R5 = H, opt. substd. alkyl, opt. substd cycloalkyl or opt. substd. cycloalkyl alkyl; with provisos.
|
