Nano and microfluidic device for separating and concentrating particles present in a fluid

摘要

A device for separating and concentrating particles present in a fluid, including: a first microchannel, having at least one first aperture; and at least one second microchannel, having at least one second aperture, and an end is disclosed. The first microchannel surrounds part or all of the second microchannel at the end. The first microchannel and the second microchannel are connected, at the end, by at least one nanochannel, the nanochannel(s) forming a restriction between the first microchannel and the second microchannel. A cap bounds the first microchannel, the second microchannel and the nanochannel at the end. The first microchannel and the second microchannel are made in a first substrate. The first aperture and the second aperture open into a same face of this substrate. The device may be used for separating and concentrating particles of biological samples, such as viruses, DNA or synthesic molecules.

主权项

1. Device for separating and concentrating particles present in a fluid, comprising:
a first microchannel, having at least one first aperture; at least one second microchannel, having at least one second aperture, and an end, wherein the first microchannel extends along a line which circumscribes the second microchannel such that the first microchannel surrounds at least part of the second microchannel at said end; the first microchannel and the second microchannel are connected, at said end, by at least one nanochannel, the nanochannel(s) forming a restriction between the first microchannel and the second microchannel, the geometry of which is fixed during a predetermined time period; and a cap bounding the first microchannel, the second microchannel and the nanochannel at said end, the first microchannel and the second microchannel being made in a first substrate, said first aperture and said second aperture opening into a same face of this substrate.