| 发明名称 | Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas | ||
| 摘要 | The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (DRR) in tumor cells, and inhibit malignant glioma cell invasion. | ||
| 申请公布号 | US9493772(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201414285184 | 申请日期 | 2014.05.22 |
| 申请人 | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY | 发明人 | Petrecca Kevin;Damha Masad;Deleavey Glen |
| 分类号 | C12N15/11;C12N15/113;A61K31/7088;A61K31/70;A61K48/00;A61K45/06 | 主分类号 | C12N15/11 |
| 代理机构 | Norton Rose Fulbright Canada LLP | 代理人 | Norton Rose Fulbright Canada LLP |
| 主权项 | 1. A method for reducing the expression of downregulated in renal cell carcinoma (DRR) in glioblastoma cells, comprising providing a therapeutic nucleic acid molecule complementary to or specifically hybridizing to DRR mRNA to the glioblastoma cells, wherein the therapeutic nucleic acid molecule reduces the expression of DRR in the glioblastoma cells. | ||
| 地址 | Montreal CA | ||