| 发明名称 |
COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA |
| 摘要 |
The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provided cationic lipids that are useful for preparing the compositions of the invention. |
| 申请公布号 |
US2016256567(A1) |
申请公布日期 |
2016.09.08 |
| 申请号 |
US201615153211 |
申请日期 |
2016.05.12 |
| 申请人 |
PROTIVA BIOTHERAPEUTICS, INC. |
发明人 |
HEYES James;PALMER Lorne R.;REID Stephen P.;YAWORSKI Edward D.;MACLACHLAN Ian;WOOD Mark;MARTIN Alan D. |
| 分类号 |
A61K48/00;A61K31/7105;A61K47/14;A61K47/28;A61K47/10;A61K9/50;A61K47/24 |
主分类号 |
A61K48/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A lipid particle comprising a cationic trialkyl lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. |
| 地址 |
Burnaby CA |
