发明名称 |
MONOCLONAL ANTIBODY SPECIFIC TO DENATURED HUMAN LEUKOCYTE ANTIGEN CLASS I |
摘要 |
<p>[PROBLEMS] To provide a monoclonal antibody capable of simultaneously detecting all the expression of three kinds of heavy chain proteins, HLA-A, HLA-B, and HLA-C that constitute human leukocyte antigen class I (HLA class I) using a denatured human tissue such as a specimen fixed with formalin or the like as a material. [MEANS FOR SOLVING PROBLEMS] It was found that an HLA class I specific antibody that preferentially binds to all the denatured HLA-A, -B and -C can be established by immunizing a mouse with a denatured recombinant HLA-A*2404 heavy chain protein. The invention is directed to the monoclonal antibody that specifically binds to the respective heavy chains of HLA-A, HLA-B and HLA-C of denatured human leukocyte antigen class I, which is produced by a hybridoma (FERM AP-20454) and specifically binds to the respective heavy chains of HLA-A, HLA-B and HLA-C of denatured human leukocyte antigen class I. Further, the invention is directed to a test agent for denatured human leukocyte antigen class I containing the monoclonal antibody as a primary component.</p> |
申请公布号 |
WO2006104085(A1) |
申请公布日期 |
2006.10.05 |
申请号 |
WO2006JP306121 |
申请日期 |
2006.03.27 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY;SATO, NORIYUKI;TORIGOE, TOSHIHIKO;SHIMOZAWA, KUMIKO;NAKAZAWA, EMIRI |
发明人 |
SATO, NORIYUKI;TORIGOE, TOSHIHIKO;SHIMOZAWA, KUMIKO;NAKAZAWA, EMIRI |
分类号 |
C07K16/18;C12N15/00;C07K19/00;G01N33/577;G01N33/58 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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