发明名称 |
SYNTHESIS AND ANTIVIRAL EVALUATION OF NUCLEIC ACID BASED (NAB) LIBRARIES |
摘要 |
The present invention provides for compositions and methods to generate a library of small molecules that mimic the repertoire of interactions that exist amongst nucleic acids, and proteins, as well as, that which exist between proteins and nucleic acids. The designed library of nucleoside analogs are for use as competitive and non-competitive viral replication inhibitors or serve as pro-drugs of inhibitors in anti-viral drug discovery. A facile parallel solution-phase chemistry has been developed to carry out the combinatorial synthesis of nucleoside analogs as a source of pharmacore-based chemical diversity. |
申请公布号 |
WO0208446(A3) |
申请公布日期 |
2002.08.15 |
申请号 |
WO2001IB02217 |
申请日期 |
2001.07.13 |
申请人 |
ORIGENIX TECHNOLOGIES, INC. |
发明人 |
IYER, RADHAKRISHNAN, P.;ZHOU, WENQIANG;JIN, YI;ROLAND, ARLENE;LYAKU, JAPHET |
分类号 |
A61K31/7052;A61P31/12;C07B61/00;C07H19/06;C07H19/16;C07H21/00;C12Q |
主分类号 |
A61K31/7052 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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