| 发明名称 |
NOVEL DUAL-TARGETING PROTEIN BINDING SPECIFICALLY TO DLL4 AND VEGF AND USE THEREOF |
| 摘要 |
The present invention relates to a novel dual-targeting protein comprising: a protein that binds specifically to delta-like ligand 4 (DLL4); and an antibody that binds specifically to vascular endothelial cell growth factor (VEGF). |
| 申请公布号 |
US2016159929(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201414903077 |
申请日期 |
2014.07.08 |
| 申请人 |
HANWHA CHEMICAL CORPORATION |
发明人 |
Lee Dong Heon;Moon Kyung Duk;Choi Yu Bin;Kang Kyung Jae;Kim Dong In;Ahn Jin Hyung;You Weon Kyoo;Jung Jinwon |
| 分类号 |
C07K16/46;C07K16/28;G01N33/574;C07K16/22 |
主分类号 |
C07K16/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A dual-targeting protein comprising: a protein specifically binding to DLL4, which recognizes a conformational epitope of DLL4 comprising amino acid residues 58th to 65th amino acid sequences and 110th to 115th amino acid sequences in amino acid sequences of DLL4 protein represented by SEQ ID NO:21, and an antibody specifically binding to VEGF (Vascular endothelial growth factor). |
| 地址 |
Seoul KR |
