Method of inducing tolerance to an allergen

摘要

The present invention relates generally to the field of allergies. More particularly, the present invention provides a method for treating an allergy in a subject by inducing tolerance to an allergen associated with the allergy. Medicinal kits useful in protocols to induce tolerance or reduce intolerance in a subject also form part of the present invention.

主权项

1. A method for treating allergen intolerance in a subject with an allergy to a food allergen, said method comprising administering to said subject a probiotic, a prebiotic agent, and the food allergen or an antigenic component thereof, in an amount effective to induce tolerance to said food allergen, wherein the food allergen is a legume allergen, wherein the probiotic is a species of Lactobacillus selected from the group consisting of Lactobacillus acidophilus NCFM, Lactobacillus casei, Lactobacillus casei Shirota, Lactobacillus casei immunitas, Lactobacillus johnsonii, Lactococcus lactis, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus salivarius, and Lactobacillus helveticus, wherein the prebiotic agent is selected from the group consisting of an oligosaccharide and a fibre, and wherein the probiotic and the food allergen are administered to the subject sequentially.