| 摘要 |
<p>This invention relates to protein-based ligand receptor molecules. In particular, this invention relates to novel 4-helix and 5-helix derivatives of seven transmembrane helix G-protein coupled receptors. Such 4-helix and 5-helix polypeptides are diagnostically and/or therapeutically useful, and also are useful for screnning for receptor antagonists and/or agonists and/or receptor ligands. Additionally, such 4-helix and 5-helix molecules are useful as substrates for the simplified production of crystals suitable for X-ray crystallographic analysis of G-protein coupled receptors.</p> |
