发明名称 |
MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULE AND METHODS BASED THEREON |
摘要 |
The present invention relates to a modified plasminogen activator inhibitor type- 1(PAI-1) molecule that displays an increased in vivo half-life of the active form of PAI- 1, but is deficient in one or more functional activities as compared to the wild-type PAI- 1 protein. The modified PAI-1 molecule that displays an increased half-life further displays at least one of the fol -lowing funtional characteristics: (i) decreased binding activity to at least one of the following molecules: urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and vitronectin (Vn); and (ii) decreased specific activity against at least one of the following molecules: uPA, tPA and Vn. The invention further relates to pharmaceutical compositions comprising modified PAI-I molecules and methods of using these pharmaceutical compositions for treatment.
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申请公布号 |
CA2722754(A1) |
申请公布日期 |
2009.01.29 |
申请号 |
CA20082722754 |
申请日期 |
2008.04.24 |
申请人 |
THE UNIVERSITY OF TOLEDO |
发明人 |
JANKUN, JERZY;SKRZYPCZAK-JANKUN, EWA;SELMAN, STEVEN H. |
分类号 |
A61K38/55;C12N15/09 |
主分类号 |
A61K38/55 |
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