METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS

摘要

PROBLEM TO BE SOLVED: To provide methods for treating pain and pruritus.SOLUTION: The present invention relates to the method for treating pain or pruritus in a patient, said method comprising administering to said patient: (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-dependent ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The first compound is an activator of the channel-forming receptor selected from TRPV1, P2X(2/3), TRPA1, and TRPM8, and the second compound inhibits voltage-dependent sodium channels or voltage-dependent calcium channels.SELECTED DRAWING: Figure 5