SENSORS FOR LONG-TERM AND CONTINUOUS MONITORING OF BIOCHEMICALS

摘要

The disclosed subject matter relates to a sensor or system for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte. The sensor of the disclosed subject matter includes a viscosity-based sensor or a permittivity-based sensor. The viscosity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber including a vibrational element. The permittivity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber. The sensor discussed herein provides excellent reversibility and stability as highly desired for long-term analyte monitoring.

主权项

1. A sensor for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte, comprising
(a) a semi-permeable membrane comprising a material permeable to the analyte; (b) a substrate; and (c) a microchamber, formed between the semi-permeable membrane and the substrate, and adapted to receive the polymer solution, such that when the analyte is placed on the semi-permeable membrane, at least a portion of the analyte will permeate the semi-permeable membrane and bind to at least a portion of the polymer solution to thereby cause a change in permittivity of the polymer solution.