发明名称 |
CYSTEINE ENGINEERED FIBRONECTIN TYPE III DOMAIN BINDING MOLECULES |
摘要 |
Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically. |
申请公布号 |
EP3057608(A2) |
申请公布日期 |
2016.08.24 |
申请号 |
EP20140854163 |
申请日期 |
2014.10.13 |
申请人 |
JANSSEN BIOTECH, INC. |
发明人 |
GOLDBERG, SHALOM;JACOBS, STEVEN;LIN, TRICIA;O'NEIL, KARYN |
分类号 |
A61K38/22;C12N1/20 |
主分类号 |
A61K38/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|