Effects of Heparin on Topical Use of Plasters Containing a Non-Steroidal Anti-Inflammatory Drug

摘要

The present invention provides for a method of improving the release of non-steroidal anti-inflammatory drugs (NSAIDs) from a plaster or bandage comprising an adhesive layer with a pharmaceutically acceptable NSAID together with heparin or a heparinoid. The invention also provides for methods of reducing muscle hyperalgesia in subjects without spontaneous pain.

主权项

1. Method of improving release of non-steroidal anti-inflammatory drugs (NSAIDs) from a bandage comprising:
a) a substrate layer; b) an adhesive layer in the form of a polymeric hydrogel matrix comprising an effective amount of a pharmaceutically acceptable NSAID and heparin or a heparinoid, at least one thickening agent, at least one wetting agent, at least one cross-linking agent; and c) a protective film which can be removed at the moment of use, wherein said hydrogel matrix further comprises a surfactant consisting of sodium ethylenediamine tetraacetate; said method comprising topically applying said bandage to patients in need thereof; and assessing an improved NSAID release compared NSAID release from bandages without heparin.