| 发明名称 |
MICE EXPRESSING A LIGHT CHAIN WITH HUMAN LAMBDA VARIABLE AND MOUSE CONSTANT REGIONS |
| 摘要 |
A transgenic mouse is provided comprising in its genome an endogenous » light chain immunoglobulin locus comprising a deletion of the endogenous mouse V»1-J»3-C»3-J»1-C»1 gene cluster and a deletion of a region spanning from V»2 to J»2 of the endogenous mouse V»2-V»3-J»2-C»2-J»4-C»4 gene cluster. Mouse cells and mouse embryos are also provided. |
| 申请公布号 |
SI2480675(T1) |
申请公布日期 |
2016.08.31 |
| 申请号 |
SI20110030867 |
申请日期 |
2011.06.22 |
| 申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
MACDONALD Lynn;STEVENS Sean;GURER Cagan;MURPHY Andrew J.;HOSIAWA Karolina A. |
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