MICRO-ORGANOIDS, AND METHODS OF MAKING AND USING THE SAME

摘要

Provided herein are micro-organoids, referred to herein as Functional Physiological Units (FPUs), that are capable of replacing or augmenting one or more physiological functions in an individual, which are useful in the treatment of individuals lacking, or suffering a deficit in, said physiological function.

主权项

1. A functional physiological unit (FPU), wherein said FPUs comprise in contiguous form an isolated extracellular matrix (ECM) and at least one type of cell, wherein said FPU performs at least one function of an organ or tissue from an organ, where said FPU is less than about 1000 microliters in volume, wherein said at least one function of an organ or tissue from an organ is production of a protein, growth factor, cytokine, interleukin, or small molecule characteristic of at least one cell type from said organ or tissue, and wherein said FPU is in administrable or injectable form.