| 摘要 |
<p>The invention provides sugar compositions for tableting by direct compression, consisting essentially of a minor fraction by weight of a substantially amorphous particulate trehalose in combination with a major fraction of one or more substances that are not directly compressible to form tablets having high integrity. The invention also provides sugar compositions for tableting by direct compression comprising a minor fraction by weight of a substantially amorphous particulate trehalose, wherein said composition is substantially free of granulating agents or binders other than said trehalose. Preferably, the compositions consist primarily of a minor fraction of powdered trehalose and a major fraction of powdered sucrose. Preferably, the amorphous trehalose is a spray dried. Also provided are methods of manufacturing a tablet by direct compression of the compositions, and tablets obtainable thereby.</p> |
