2-amino, 6-phenyl substituted pyrido [2,3-d] pyrimidine derivatives useful as raf kinase inhibitors

摘要

Disclosed is the compound 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (DP-4978 / LSN 3074753 / LY-3009120) or a pharmaceutically acceptable salt thereof which is a pan Raf Inhibitor. Also disclosed are crystalline forms of the compound. Further disclosed is a pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable carrier, for the treatment of cancer, particularly thyroid cancer, ovarian cancer, melanoma, acute myelogenous leukemia (AML), and colorectal cancer.