Combination therapy with low dosage strength imiquimod and photodynamic therapy to treat actinic keratosis

摘要

This disclosure is directed to the use of sequentially applied topical therapy with a lower dosage strength imiquimod composition and photodynamic therapy for treating actinic keratosis, wherein the photodynamic therapy is administered subsequent to the topical therapy with the imiquimod composition. In some embodiments, the imiquimod composition comprises from about 1% (w/w) to about 4.25% (w/w) imiquimod.

主权项

1. A method of treating actinic keratosis (AK) in a subject in need thereof, the method comprising:
topically applying to a treatment area on the subject an imiquimod composition comprising from about 1% (w/w) to about 4.25% (w/w) imiquimod, wherein the step of applying the imiquimod composition to the treatment area comprises a first treatment and a second treatment period, wherein the first and second treatment periods are separated by a non-treatment period and wherein each of the first treatment period, the second treatment period, and the non-treatment period is for a length of time of up to three weeks; and subsequent to the topical application of the imiquimod composition, administering photodynamic therapy to the treatment area or to an AK lesion in the treatment area, wherein the photodynamic therapy treatment is administered within four weeks after completion of the imiquimod treatment; thereby treating AK in the subject.