发明名称 |
Eukaryotes expressing single stranded hybrid molecules |
摘要 |
Eucaryotic cells like mammal and plant cells transfected with genes, called retrons, which code for stable single-stranded hybrid molecules (msDNA) containing RNA and DNA portions are disclosed. The retrons producing said linked RNA and DNA portions of the msDNAs also contain a gene encoding a reverse transcriptase (RT), which is necessary for the synthesis of the msDNAs. The msDNAs may contain foreign nucleic acid fragments which may be antisense fragments. These msDNA antisense vectors are useful for targeting genes of target proteins.
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申请公布号 |
US5849563(A) |
申请公布日期 |
1998.12.15 |
申请号 |
US19950507634 |
申请日期 |
1995.07.25 |
申请人 |
THE UNIVERSITY OF MEDECINE AND DENTISTRY OF NEW JERSEY |
发明人 |
MIYATA, SHOHEI;OHSHIMA, ATSUSHI;INOUYE, SUMIKO;INOUYE, MASAYORI |
分类号 |
C12N9/12;C12N15/10;C12N15/113;C12N15/81;C12P19/34;(IPC1-7):C12N5/10;C12N1/15 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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