发明名称 |
RON INHIBITORS FOR USE IN PREVENTING AND TREATING BONE LOSS |
摘要 |
Provided herein are methods for inhibiting osteolysis or treating osteoporosis in a subject in need thereof, the method including administering to the subject at least one RON inhibitor. The osteolysis may be caused by a condition selected from the group consisting of cancer, inflammation, and cyst. The condition may include a bone tumor or a tumor located in bone. The subject may have been diagnosed with bone cancer. The inhibitor may be ASLAN002. The inhibitor may be OSI-296. The inhibitor may be selective or specific for RON. The inhibitor may not depend on the function of RANKL or TGFβ. |
申请公布号 |
US2016367534(A1) |
申请公布日期 |
2016.12.22 |
申请号 |
US201515122353 |
申请日期 |
2015.03.13 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
Welm Alana L.;Andrade Kelsi Kretschmann |
分类号 |
A61K31/444 |
主分类号 |
A61K31/444 |
代理机构 |
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代理人 |
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主权项 |
1. A method for inhibiting osteolysis or treating osteoporosis in a subject in need thereof, the method comprising administering to the subject an effective amount of at least one RON inhibitor. |
地址 |
Salt Lake City UT US |