发明名称 |
CHIMERIC ANTIGEN RECEPTORS RECOGNIZING CANCER-SPECIFIC TN GLYCOPEPTIDE VARIANTS |
摘要 |
Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer- specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated T cell. Also disclosed are polynucleotides encoding such binding proteins, including polynucleotides comprising codon- optimized coding regions and polynucleotides comprising coding regions that are not codon- optimized for expression in a particular host cell. Also disclosed are methods of making the encoded polypeptide and methods of using the polypeptide to treat, prevent or ameliorate the symptom of a disease such as cancer. |
申请公布号 |
EP3102236(A1) |
申请公布日期 |
2016.12.14 |
申请号 |
EP20150746143 |
申请日期 |
2015.02.05 |
申请人 |
The University of Chicago |
发明人 |
SCHREIBER, Hans;IDEL, Christian;ENGELS, Boris |
分类号 |
A61K39/395;C07K16/46;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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