发明名称 |
HYPERBRANCHED POLYGLYCEROL SULFATES WITH HYDROPHOBIC CORES |
摘要 |
The present invention relates to the field of drug carrier systems and polymer therapeutics and diagnostics. It provides derivatized unimolecular polyols with a hydrophobic core moiety and a polyanionic, preferably, sulfated hydrophilic shell, N in particular to unimolecular hyperbranched sulfated polyglycerol micelles having a hydrophilic shell and a hydophrobic core. These may be used for the supramolecular encapsulation and transport of hydrophobic guest molecules into biological systems. The micelles can be applied as a drug carrier system for therapy and for diagnosis. They may also be therapeutic agents on their own. The invention also relates to preparation of said micelles. |
申请公布号 |
US2017119898(A1) |
申请公布日期 |
2017.05.04 |
申请号 |
US201515129348 |
申请日期 |
2015.03.24 |
申请人 |
DENDROPHARM GMBH |
发明人 |
PAULUS Florian;HAAG Rainer |
分类号 |
A61K9/50;A61K9/00;C08G65/48;A61K31/704;A61K9/107 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
1. A unimolecular sulfated polyglycerol micelle having a hydrophilic shell and a hydrophobic core. |
地址 |
Berlin DE |