| 主权项 |
1. A compound having formula (I): Including hydrates, solvates, pharmaceutically acceptable salts, prodrugs, enantiomers, and complexes thereof, wherein: A is selected from the group consisting of z is 0, 1, or 2; When A is R1 is selected from the group consisting of When A is and z is 0, R1 is When A is and z is 1, R1 is When A is and z is 2, R1 is selected from the group consisting of When R1 is n is not 0; When R1 is n is not 0; When R1 is n is not 0; R2 is W is (CH2)m; m is 1 or 2; Y is (CH2)q; q is 1 or 2; n is 0, 1, 2, or 3; b is 0, 1, 2, or 3; d is 0, 1, 2, or 3; R3 is selected from the group consisting of COR5, CO2R6, CONR7aR7b, SO2NR7aNR7b, SO2R8, and optionally substituted heteroaryl; R4a and R4b are each independently selected from the group consisting of hydrogen and C1-6 alkyl; R4c is selected from the group consisting of hydrogen and OH; R5 is selected from the group consisting of hydrogen, C1-6 alkyl, optional substituted heteroaryl, —C(R9aR9b)NR7aNR7b, and —C(R9aR9b)OR10; R5 is also selected from optional substituted C1-6 alkyl; R6 is C1-6 alkyl; R6 is also selected from optional substituted C1-6 alkyl; R7a and R7b are each independently selected from the group consisting of hydrogen and C1-6 alkyl; R7a and R7b are also each independently selected from optional substituted C1-6 alkyl; R8 is selected from the group consisting of hydrogen, C1-6 alkyl and optional substituted heteroaryl; R8 is also selected from optional substituted C1-6 alkyl; R9a and R9b are each independently selected from the group consisting of hydrogen, C1-6 alkyl, C3-7 branched alkyl, CH2OH, CH(OH)CH3, CH2Ph, CH2(4-OH-Ph), (CH2)4NH2, (CH2)3NHC(NH2)NH, CH2(3-indole), CH2(5-imidazole), CH2CO2H, CH2CH2CO2H, CH2CONH2, and CH2CH2CONH2; R10 is selected from the group consisting of hydrogen and C1-6 alkyl. |
