Methods and compositions related to annexin 1-binding compounds

摘要

Disclosed are conjugates comprising the annexin 1-binding peptide IFLLWQR covalently linked to a therapeutic or detectable agent. Also disclosed are compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods of targeting a tumor cell in a subject comprising administering to the subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. The disclosed targeting is useful for treatment of, for example, cancer.

主权项

1. A composition comprising a linear peptide and a moiety, wherein the linear peptide comprises an amino acid sequence that can bind to a carbohydrate receptor on a cell, wherein:
the amino acid sequence comprises IFLLWQRX (SEQ ID NO:25), IFLLWQRXX (SEQ ID NO:26), IFLLWQRXXX (SEQ ID NO:27), IFLLWQRXXXX (SEQ ID NO:20), or IFLLWQRXXXXX (SEQ ID NO:28), wherein the subsequence IFLLWQR (amino acids 1 to 7 of SEQ ID NO:28) in the amino acid sequence is an annexin-1 binding compound and has one or more conservative amino acid substitutions, wherein each X can independently be selected from all, any set of 8, any set of 7, any set of 6, any set of 5, any set of 4, any set of 3, any set of 2, or any 1 of the amino acids R, S, T, H, D, E, N and Q, wherein the linear peptide is a targeting peptide and wherein the moiety is selected from the group consisting of detectable agents and therapeutic agents.