发明名称 |
ADENO-ASSOCIATED VIRUS FACTOR VIII VECTORS, ASSOCIATED VIRAL PARTICLES AND THERAPEUTIC FORMULATIONS COMPRISING THE SAME |
摘要 |
The invention provides adeno-associated virus (AAV) Factor VIII (FVIII)- encoding/expressing vectors and virus, including AAV FVIII vectors with high expression activity and AAV FVIII vectors that express full-length or truncated functional FVIII protein. The invention also relates to methods of making the herein described AAV FVIII vectors, recombinant AAV FVIII virus particles comprising or expressing such vectors, associated pharmaceutical formulations comprising the same and therapeutic uses thereof. |
申请公布号 |
WO2017053677(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
WO2016US53269 |
申请日期 |
2016.09.23 |
申请人 |
BIOMARIN PHARMACEUTICAL INC. |
发明人 |
BUNTING, Stuart;COLOSI, Peter, Cameron;PUNGOR, Erno |
分类号 |
A61K39/12;C07K14/755 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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