| 发明名称 |
CELL SURFACE COUPLING OF NANOPARTICLES |
| 摘要 |
The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor. |
| 申请公布号 |
US2017080104(A1) |
申请公布日期 |
2017.03.23 |
| 申请号 |
US201615236186 |
申请日期 |
2016.08.12 |
| 申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
IRVINE Darrell J.;ZHENG Yiran;Tang Li |
| 分类号 |
A61K9/127;A61K39/00;C07K14/55;C07K16/30;C07K14/705;C07K14/725;C12N5/0783;C07K19/00 |
主分类号 |
A61K9/127 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a nucleated carrier cell that homes to a tumor and is coupled to a nanostructure comprising a biologically active protein, wherein the carrier cell comprises a CD45 receptor and is coupled to the nanostructure with a ligand that binds the CD45 receptor or the carrier cell comprises a negatively charged cell membrane and the nanostructure comprises a polycation surface which interacts electrostatically with the cell membrane, and wherein the nanostructure is a protein nanogel or a liposome. |
| 地址 |
Cambridge MA US |
