发明名称 Heteroarylamine derivatives as protein kinase inhibitors
摘要 A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an active ingredient.
申请公布号 US9586936(B2) 申请公布日期 2017.03.07
申请号 US201514947204 申请日期 2015.11.20
申请人 KOREA INSTITITUE OF SCIENCE AND TECHNOLOGY 发明人 Sim Tae Bo;Yoon Ho Jong;Yoon Ji Hye;Hur Woo Young;Roh Eun Joo;Kwak Yeon Ui
分类号 A61K31/506;C07D403/04;C07D401/14;C07D471/04;C07D487/04 主分类号 A61K31/506
代理机构 Goldilocks Zone IP Law 代理人 Goldilocks Zone IP Law
主权项 1. A compound selected from a heteroarylamine compound represented by Chemical Formula 1, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof: wherein, R1 is one to four substituent(s) selected from a halogen atom, C1-C8 alkyl, C1-C8 alkoxy and R2 is a hydrogen atom, C1-C8 alkyl, —(CH2)m—NR3R4 or -A-(CH2)n-(Q)p-R5, A is C6-C15 aryl, 5- or 6-membered heteroaryl containing one to three nitrogen atom(s) or 5- or 6-membered heterocycloalkyl containing one to three heteroatom(s) selected from a nitrogen atom and an oxygen atom, wherein each of the aryl, heteroaryl or heterocycloalkyl may be substituted or unsubstituted with one to three substituent(s) selected from C1-C8 alkyl, C1-C8 alkoxy, C1-C8 haloalkyl and C1-C8 alkoxycarbonyl, L is —NHC(O)— or —C(O)NH—, Z is one to four substituent(s) selected from C1-C8 alkyl, C1-C8 haloalkyl, 5- or 6-membered heteroaryl containing one to three nitrogen atom(s) and 5- or 6-membered heterocycloalkyl containing one to three heteroatom(s) selected from a nitrogen atom and an oxygen atom, wherein the heteroaryl or heterocycloalkyl may be substituted or unsubstituted with C1-C8 alkyl, Q is 5- or 6-membered heterocycloalkyl or biheterocycloalkyl containing one to three heteroatom(s) selected from a nitrogen atom and an oxygen atom, each of R3 and R4 is a hydrogen atom or C1-C8 alkyl, R5 is a hydrogen atom, C(O)OR7 (wherein R7 is a hydrogen atom or C1-C8 alkyl) or C1-C8 alkyl, m is an integer from 1 to 6, n is an integer from 0 to 6, p, which indicates the presence or absence of Q, is 0 or 1, and wherein X1 and X4 are N and X2 and X3 are CH.
地址 Seoul KR