发明名称 |
THYMIDYLATE KINASE FUSIONS AND USES THEREOF |
摘要 |
The application relates to a composition comprising:
a stably integrating delivery vector;a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; anda detection cassette fused to tmpk.;The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer. |
申请公布号 |
US2017056527(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
US201615211586 |
申请日期 |
2016.07.15 |
申请人 |
University Health Network |
发明人 |
Medin Jeffrey A.;Devine Sean |
分类号 |
A61K48/00;C07K14/705;C12N15/86;C12N9/12 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Toronto CA |