Composition for therapeutic use, including an organic lipid phase and a rare-earth radioisotope complex

摘要

The invention relates to a therapeutic composition including a complex having the following formula (1), including a rare-earth radioisotope in ionic form, said complex being solubilized in an organic lipophilic phase: [M(L)3] in which: M denotes the rare-earth radioisotope in ionic form, and L denotes a tropolone ligand or a ligand derived from tropolone.

主权项

1. A therapeutical composition, comprising a complex having the following formula (1) comprising a rare-earth radioisotope, said complex being solubilized in a lipophilic organic phase:
[M(L)3]  (1)wherein:
M designates the rare-earth radioisotope, wherein the rare-earth radioisotope is 90Y or 47Sc, and L designates a tropolone ligand or a tropolone-derived ligand chosen from amongst halogenotropolone, α-methyltropolone, β-methyltropolone, γ-methyltropolone, α-isopropyltropolone, β-isopropyltropolone, γ-isopropyltropolone, nootkatin, stipitatic acid, puberulic acid, puberulonic acid, purpurogallin, or colchicine.