| 发明名称 |
Modified Host Cells Having Tolerance to Alpha-Olefins |
| 摘要 |
The present invention provides methods for improving microbial tolerance to alpha olefin compounds, host cells having increased tolerance to such compounds, and method of using the host cells to produce alpha olefin compounds. |
| 申请公布号 |
US2017051317(A1) |
申请公布日期 |
2017.02.23 |
| 申请号 |
US201515307783 |
申请日期 |
2015.04.29 |
| 申请人 |
The Regents of the University of California ;Total Marketing Services |
发明人 |
Mukhopadhyay Aindrila;Mingardon Florence;Chanal Angelique |
| 分类号 |
C12P5/02;C07K14/245 |
主分类号 |
C12P5/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A microorganism host cell comprising a recombinant non-naturally occurring variant AcrB-like polypeptide that comprises at least one amino acid sequence mutation relative to a native AcrB-like polypeptide sequence, wherein the non-naturally occurring AcrB-like polypeptide reduces accumulation of alpha-olefin compounds in the host cell in comparison to a wild-type host cell that expresses the native AcrB-like polypeptide at a native level. |
| 地址 |
Oakland CA US |
