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1. An oligooxopiperazine having a formula selected from the group consisting of:
(i) Formula IA: wherein: R1 and R2 are each independently an aromatic amino acid side chain; R3 is an alkyl or aryl; R4 and R7 are each independently a solubilizing group, a hydrophobic amino acid side chain, H, N(R)2, OR, halogen, an alkyl, or an aryl; wherein each R is independently H, an alkyl, or an aryl; R5 is an alkyl; each R6 is independently H, halogen, an alkyl, or an aryl; X1 is H, N(R)2, OR, COR′, CO2R′, CONR′, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a peptide of 1 to 5 amino acid residues, a peptide of 1 to 6 amino acid residues, a peptide of 1 to 7 amino acid residues, a peptide of 1 to 8 amino acid residues, a peptide of 1 to 9 amino acid residues, a peptide of 1 to 10 amino acid residues, a peptide of 1 to about 10 amino acid residues, a protecting group for protection of an amine, a solubilizing group, a targeting moiety, or a tag; wherein each R is independently H, an alkyl, or an aryl; and wherein R′ is H, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; with the proviso that X1 is absent when Z is O or S; Z is N, O, or S; each A1-W1 is independently: and Y is OR′, COR′, N(R′″)2, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, an amino acid, a peptide of 1 to 5 amino acid residues, a peptide of 1 to 6 amino acid residues, a peptide of 1 to 7 amino acid residues, a peptide of 1 to 8 amino acid residues, a peptide of 1 to 9 amino acid residues, a peptide of 1 to 10 amino acid residues, a peptide of 1 to about 10 amino acid residues, a protecting group for protection of a carboxylic acid, a targeting moiety, or a tag; wherein R′ is H, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; and wherein each R′″ is independently H, CO2R′, CONR′, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; (ii) Formula IB: wherein: R1 and R2 are each independently an aromatic amino acid side chain; R3 is an alkyl or aryl; R4 is an alkyl; each R6 is independently H, halogen, an alkyl, or an aryl; X1 is H, N(R)2, OR, COR′, CO2R′, CONR′, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a peptide of 1 to 5 amino acid residues, a peptide of 1 to 6 amino acid residues, a peptide of 1 to 7 amino acid residues, a peptide of 1 to 8 amino acid residues, a peptide of 1 to 9 amino acid residues, a peptide of 1 to 10 amino acid residues, a peptide of 1 to about 10 amino acid residues, a protecting group for protection of an amine, a solubilizing group, a targeting moiety, or a tag; wherein each R is independently H, an alkyl, or an aryl; and wherein R′ is H, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; with the proviso that X1 is absent when Z is O or S; Z is N, O, or S; A1-W1 is: and Y is OR′, COR′, N(R′″)2, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, an amino acid, a peptide of 1 to 5 amino acid residues, a peptide of 1 to 6 amino acid residues, a peptide of 1 to 7 amino acid residues, a peptide of 1 to 8 amino acid residues, a peptide of 1 to 9 amino acid residues, a peptide of 1 to 10 amino acid residues, a peptide of 1 to about 10 amino acid residues, a protecting group for protection of a carboxylic acid, a targeting moiety, or a tag; wherein R′ is H, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; and wherein each R′″ is independently H, CO2R′, CONR′, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; and (iii) Formula IC: wherein: R0 and R3 are each independently an aromatic amino acid side chain; R1 and R2 are each independently a solubilizing group, a hydrophobic amino acid side chain, H, N(R)2, OR, halogen, an alkyl, or an aryl; wherein each R is independently H, an alkyl, or an aryl; R4 is an alkyl; each R6 is independently H, halogen, an alkyl, or an aryl; X′ is H, COR′, CO2R′, CONR′, OR′, N(R″)2, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a solubilizing group, a targeting moiety, or a tag; wherein R′ is H, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, an amino acid residue, a peptide of 1 to 5 amino acid residues, a peptide of 1 to 6 amino acid residues, a peptide of 1 to 7 amino acid residues, a peptide of 1 to 8 amino acid residues, a peptide of 1 to 9 amino acid residues, a peptide of 1 to 10 amino acid residues, a peptide of 1 to about 10 amino acid residues, a targeting moiety, or a tag; and wherein each R″ is independently H, CO2R′, CONR′, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; A1-W1 is: and Y is OR′, COR′, N(R′″)2, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, an amino acid, a peptide of 1 to 5 amino acid residues, a peptide of 1 to 6 amino acid residues, a peptide of 1 to 7 amino acid residues, a peptide of 1 to 8 amino acid residues, a peptide of 1 to 9 amino acid residues, a peptide of 1 to 10 amino acid residues, a peptide of 1 to about 10 amino acid residues, a protecting group for protection of a carboxylic acid, a targeting moiety, or a tag; wherein R′ is H, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag; and wherein each R′″ is independently H, CO2R′, CONR′, an alkyl, an aryl, an arylalkyl, a cycloalkyl, a heteroaryl, a targeting moiety, or a tag. |
