| 发明名称 |
SUSTAINED-RELEASE DRUG FORMULATIONS FOR GLAUCOMA |
| 摘要 |
A polymer-drug conjugate includes a crosslinked polymer network comprising a biocompatible polymer and a multivalent covalent crosslinker, wherein the multivalent crosslinker comprises an active ingredient precursor covalently bonded through two or more bonds to the biocompatible polymer, and wherein the covalent bond is a hydrolysable bond. The drug can be for treatment of glaucoma and the free drug is biologically active and selected to lower eye pressure. |
| 申请公布号 |
US2017028078(A1) |
申请公布日期 |
2017.02.02 |
| 申请号 |
US201615221257 |
申请日期 |
2016.07.27 |
| 申请人 |
LayerBio, Inc. |
发明人 |
MANDELL Kenneth;WHITE Aleksandr |
| 分类号 |
A61K47/48;A61K31/5575;C08G69/48;A61K9/00 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polymer-drug conjugate comprising:
a crosslinked polymer network comprising a biocompatible polymer and a multivalent covalent crosslinker,
wherein the multivalent crosslinker comprises an active ingredient precursor covalently bonded through two or more bonds to the biocompatible polymer, andwherein the covalent bond is a hydrolysable bond. |
| 地址 |
Arlington MA US |
