Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors

摘要

Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.

主权项

1. A radiation treatment system comprising:
planning software, spreadsheet or nomogram adapted to guide a user in planning radiation treatment of mammalian tissue, the planning software, spreadsheet or nomogram providing the user with at least a quantity of radioactive seeds to be used in the radiation treatment based on one or more of a preoperative shape of a treatment area, size of a lesion within the treatment area, anatomical location of the treatment area, or histology of the mammalian tissue; a plurality of radioactive seed carriers as determined by the planning software, spreadsheet or nomogram, each of the plurality of radioactive seed carriers comprising a biocompatible material having a top surface, an opposing bottom surface, and a thickness of between four and seven millimeters therebetween, wherein the top surface and the bottom surface are substantially rectangular with each side of the rectangle having a length of at least one centimeter; a plurality of radioactive seeds encased within one or more titanium layers, one or more of the plurality of the radioactive seeds configured for implantation into respective radioactive seed carriers, each of the radioactive seeds comprising Cesium-131 emitting radiation configured to kill living cells; and a loading device comprising:
a planar surface defining a loading bed perpendicular to sides of the loading device and adapted to support one of the plurality of radioactive seed carriers abutting a first side of the sides of the loading device; anda guide channel disposed in the first side of the sides of the loading device, the guide channel configured to receive and direct a guide tool parallel to the planar surface, the a guide tool configured to move one or more of the plurality of radioactive seeds into and at least partially through the radioactive seed carrier supported on the loading bed of the loading device; wherein the plurality of radioactive seed carriers each embedding respective radioactive seeds are configured for custom placement with reference to one another near or in the treatment area in order to customize radiation delivered from the embedded radioactive seeds to the treatment area and minimize radiation delivered outside the treatment area.