| 主权项 |
1. A compound of Formula I: or pharmaceutically acceptable salt, tautomer, or stereoisomer thereof wherein: L1 is straight or branched C2-C4 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, D, OR10, NH2, NHR10, and N(R10)(R10′), provided that no more than one oxygen or nitrogen is attached to any carbon; or L1 is selected from the group consisting of —CO—C1-C2alkylenyl-, —S(O)2—, —S(O)2NH—, —C(O)NH—, —C(O)NR10—, —C1-C3alkylenyl-C(O)—C1-C3alkylenyl-, and a bond, wherein the C1-C2 alkylenyl and C1-C3 alkylenyl is optionally substituted with C1-C4 alkyl;
Each R10 and R10′ is independently selected from the group consisting of H; O—C1-C5 alkyl; C1-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, O—C1-C5 alkyl, —OP(O)(OH)2, OP(O)O2−2M2, —OC(O)alkyl, —OC(O)Oalkyl, and aryl; and cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and O—C1-C5 alkyl;provided that no more than one oxygen is attached to any carbon of R10 and R10′;M is a monovalent metal cation; R1 is aryl optionally substituted with one or more substituents selected from the group consisting of OH, CN, halogen, —O—R10, —OP(O)(OH)2, OP(O)O2−2M2, —SH, —S—R10, C1-C5 alkyl, branched alkyl, —C1-C6haloalkyl, NH2, NHR10, —C1-C6hydroxyalkyl, N(R10)(NR10′), —NHS(O)2R10, —O-alkylaryl, —O—(CH2)—C(O)-aryl, and NHCOR10; M is a monovalent metal cation; or R1 is cycloalkyl; X is selected from the group consisting of H, halogen, OH, O—C1-C6 alkyl, O-branched alkyl, C1-C5 straight alkyl and C1-C5 branched alkyl; Y and Y′ are independently H, F, or methyl; L2 is —(CH2)n— or —(CHR11)n—, or a bond;
Each R11 is independently selected from the group consisting of H, —C1-C5 alkylenyl-, —C(O)—C1-C5alkylenyl-, and -alkylenyl-CO-alkylenyl-; R2 is C3-C8cycloalkyl; phenyl, or naphthyl, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, C1-C6alkyl, OR10, CN, NH2, NHR10, N(R10)(R10′), SH, SR10, SOR10, SO2R10, SO2NHR10, SO2N(R10)(R10′), CONH2, CONR10, and CON(R10)(R10′); and n is 1, 2, or 3. |
