发明名称 |
Anti-MUC1 antibody or antigen-binding fragment of same, and use thereof |
摘要 |
The present invention provides: an antibody exhibiting specificity for MUC1, the antibody having a glycan structure expressed at high levels in cancer cells; a method for manufacturing this antibody; and a novel means and method for the diagnosis and prevention and/or treatment of cancer using this antibody. The present invention is a monoclonal antibody to human MUC1, wherein the antibody specifically recognizes a glycopeptide having a human MUC1 tandem unit and furthermore having an O-linked glycan core (0(Tn)) in any one of the threonine and serine in the amino acid sequence of this human MUC1 tandem unit. A method for detecting MUC1 in a human body-fluid sample. A kit including this monoclonal antibody. A pharmacological composition for the prevention and/or treatment of a malignant tumor, the pharmacological composition containing this monoclonal antibody as an active ingredient. |
申请公布号 |
AU2015254257(A9) |
申请公布日期 |
2017.01.05 |
申请号 |
AU20150254257 |
申请日期 |
2015.04.28 |
申请人 |
Medicinal Chemistry Pharmaceuticals, Co. |
发明人 |
Nishimura Shinichiro;Miyoshi Risho;Naruchi Kentaro;Tanaka Masakazu;Sato Masaharu |
分类号 |
C07K16/28;A61K39/395;A61P35/00;C12P21/08;C12Q1/02;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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