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1. Compounds of Formula (I): and stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, wherein: A1 is O, CH2 or S; A2 is NH or N—C1-C3-alkyl; A3 is N or CR2; A4 is N or CR3, provided that A3 and A4 are not N at the same time; R1 is Cl, NO2, or CN; R2 and R6 are independently selected from the group consisting of H, halo, hydroxy, C1-C6-hydroxyalkyl, and NH2; R3 and R5 are independently selected from the group consisting of: H; hydroxy; halo; —C1-C6-alkyl-Rf; —C1-C6-alkenyl-Rf; —C1-C6-alkoxy-Rc; —NRaRb; —NRa—(C1-C6-alkyl)-Rd; —NRa—S(O)2-(4 to 10 membered heterocycloalkyl); —NRa—(C3-C8-cycloalkyl), which cycloalkyl is unsubstituted or substituted by C1-C6-alkyl or a C1-C3-alkylene bridge; —NRa-aryl, which aryl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, —NH2, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-hydroxyalkyl, C1-C6-haloalkoxy and C3-C8-cycloalkyl; —NRa-(4 to 10 membered heterocycloalkyl), which heterocycloalkyl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: C1-C6-alkyl, C1-C6-hydroxyalkyl, or —CO-alkyl; —NRa-(5 or 6 membered heteroaryl), which heteroaryl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, —NRaRb and C1-C6-alkyl; —NRa(CO)—C1-C6-alkyl; —NRa(CO)-aryl; —NRa(CO)-(5 or 6 membered heteroaryl); —NRa(CO)O—C1-C6-alkyl; —S-(alkyl)n-Rh; —S(O)2-aryl, which aryl is unsubstituted or substituted by one or more halo; —C(O)—Re; —C(O)NRa—(C1-C6-alkyl)n-Rg; —C(O)NRa—C1-C6-alkoxy; —O—C3-C8-cycloalkyl, which cycloalkyl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo or hydroxy, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkoxyaryl, C1-C6-haloalkyl, C1-C6-hydroxyalkyl, NRaRb, aryl, C1-C6-akyl-aryl, 5 or 6 membered heteroaryl, and —(C1-C6-alkyl)-(C1-C6-alkoxy); —O-aryl, which aryl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkyl-C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-hydroxyalkyl, —S—C1-C6-akyl, —C1-C6-alkyl-C3-C8-cycloalkyl, C1-C6-alkoxy-C3-C8-cycloalkyl, C1-C6-alkyl-(4 to 10 membered heterocycloalkyl), C1-C6-alkyl-(5 or 6 membered heterocycloalkyl), or 5 or 6 membered heteroaryl unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: C1-C6-alkyl, —(C1-C6-alkyl)-(C1-C6-alkoxy), C1-C6-haloalkoxy and a C1-C6-alkylene bridge; —O-(4 to 10 membered heterocycloalkyl), which heterocycloalkyl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, C1-C6-alkyl, C1-C6-hydroxyalkyl and —C(O)—C1-C6-alkyl; —O-(5 to 10 membered heteroaryl), which heteroaryl is unsubstituted or substituted by halo, C1-C6-alkyl, C1-C6-hydroxyalkyl, or —NRa(CO)—C1-C6-akyl; C3-C8-cycloalkyl, which cycloalkyl may be fused to a phenyl; aryl unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, —C(O)OH, C1-C6-hydroxyalkyl, C1-C6-alkoxy, —S(O)2—NH(alkyl) and —S(O)2—N(alkyl)2; 4 to 10 membered heterocycloalkyl unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, C1-C6-alkyl, —C(O)—C3-C8-cycloalkyl, oxo and 5 or 6 membered heterocycloalkyl; 5 to 10 membered heteroaryl unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-hydroxyalkyl, and 4 to 10 membered heterocycloalkyl; R4 is:
H,cyano,halo,hydroxy,NRaRb,C1-C6-alkyl,C1-C6-haloalkyl,C1-C6-hydroxyalkyl,C1-C6-alkoxy unsubstituted or substituted by hydroxy, C1-C6-alkoxy or NRaRb,—(C1-C6-alkyl)n-(C3-C8-cycloalkyl), unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, —C(O)—C1-C6-alkyl, —C(O)—C1-C6-cycloalkyl; —C(O)-(5 or 6 membered heterocycloalkyl);—(C1-C6-alkyl)n-(C3-C8-cycloalkenyl), unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, —C(O)—C1-C6-alkyl, —C(O)—C1-C6-cycloalkyl and —C(O)-(5 or 6 membered heterocycloalkyl);—(C1-C6-alkyl)n-(5 or 6 membered heteroaryl), unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl and —C(O)—C1-C6-alkyl, —C(O)—C1-C6-cycloalkyl and —C(O)-(5 or 6 membered heterocycloalkyl);—(C1-C6-alkyl)n-(4 to 10 membered heterocycloalkyl) unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, cyano, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-hydroxyalkyl, —C(O)OH, a C1-C4-alkylene bridge, —C(O)—C1-C6-alkyl, —C(O)—C3-C8-cycloalkyl, —C(O)-aryl, —C(O)(4 to 10 membered heterocycloalkyl) and —C(O)-(5 or 6 membered heterocycloalkyl); R7 is aryl, a 5 or 6 membered heterocycle or 5 or 6 membered heteroaryl which aryl, heterocycle or heteroaryl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of halo, C1-C6-alkyl, C3-C8-cycloalkyl, —O-aryl, —S-aryl, —NH-aryl, and —(C1-C6-alkyl)n-aryl; or R6 and R7 together with the carbon atoms to which they are attached form a 5 membered ring selected from a cycloalkyl or heterocycloalkyl having 5 ring members; R8 is OH, —NRaRb, C1-C6-alkoxy or —C(O)O—C1-C6-alkyl; or R2 and R3 together with the atoms to which they are attached form a naphthyl or 9 or 10 membered heteroaryl, each of which is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of:
halo, hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy and C1-C6-haloalkyl;or R3 and R4 together with the atoms to which they are attached form a naphthyl or 9 or 10 membered heteroaryl, each of which is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of:halo, hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy and C1-C6-haloalkyl;or R4 and R5 together with the atoms to which they are attached form a naphthyl or 9 or 10 membered heteroaryl, each of which is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of:halo, hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy and C1-C6-haloalkyl; or R5 and R6 together with the atoms to which they are attached form a naphthyl or 9 or 10 membered heteroaryl, each of which is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, hydroxy, —NRaRb, C1-C6-alkyl, C1-C6-alkoxy and C1-C6-haloalkyl; Ra is H or C1-C6-alkyl; Rb is H or C1-C6-alkyl; Rc is H, hydroxy, halo, —NRaRb, C1-C6-alkoxy, C1-C6-alkenyl, 4 to 6 membered heterocycloalkyl unsubstituted or substituted by oxo or C1-C6-alkyl, 5 or 6 membered heteroaryl unsubstituted or substituted by C1-C6-alkyl, or C3-C8-cycloalkyl unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, C1-C6-alkyl or C1-C6-hydroxyalkyl, aryl unsubstituted or substituted by halo, 4 to 9 membered heterocycloalkyl unsubstituted or substituted by oxo or C1-C6-alkyl, and 5 or 6 membered heteroaryl unsubstituted or substituted by C1-C6-alkyl; Rd is H, hydroxy, C1-C6-alkyl, C3-C8-cycloalkyl or aryl unsubstituted or substituted by one or more substituent(s) selected from the group consisting of halo and —NRa—S(O)2—N(C1-C6-alkyl)2; Re is C1-C6-alkyl, aryl, C3-C8-cycloalkyl, 5 to 9 membered heterocycloalkyl or 5 or 6 membered heteroaryl and wherein said aryl, C3-C8-cycloalkyl, 5 to 9 membered heterocycloalkyl or 5 or 6 membered heteroaryl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of: halo, C1-C6-alkoxy, C1-C6-alkyl and C1-C6-haloalkyl; Rf is H, C3-C8-cycloalkyl, 4 to 10 membered heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl, which cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of halo, C1-C6-haloalkyl, C1-C6-alkyl, C1-C6-alkoxy and C1-C6-hydroxyalkyl; Rg is C1-C6-alkoxy, C3-C8-cycloalkyl, aryl, 5 or 6 membered heteroaryl, 5 to 9 membered heterocycloalkyl, wherein said aryl, C3-C8-cycloalkyl, 5 to 9 membered heterocycloalkyl or 5 or 6 membered heteroaryl is unsubstituted or substituted by one or more substituent(s) selected from the group consisting of halo, C1-C6-alkoxy and C1-C6-hydroxyalkyl; Rh is aryl, 5 or 6 membered heteroaryl, 4 to 10 membered heterocycloalkyl, C3-C8-cycloalkyl, each of which is unsubstituted or substituted by halo; n is 0 or 1. |
