| 摘要 |
A method of preparing a coated polymeric surface, the method comprising providing a polymeric surface, exposing the surface to a coating formulation and polymerizing the coating formulation on the polymeric surface to obtain the coated polymeric surface; wherein the coating formulation comprises a thiol monomer, an unsaturated monomer and a therapeutic agent. Preferably the thiol monomer is a polythiol and the unsaturated monomer has more than one unsaturated bond, more preferably the thiol monomer is pentaerythritol tetrakis(3-mercaptopropionate) and the unsaturated monomer is triallyl isocyanurate. The therapeutic agent preferably comprises an antibiotic, more preferably rifampicin, minocycline, minocycline hydrochloride and/or minocycline hyclate. The coating formulation may also comprise a radical scavenger, polymerization initiators and/or solvents. The polymeric surface to be coated is preferably expanded polytetrafluoroethylene, polytetrafluoroethylene, polypropylene or polyester. The polymeric coating of the invention may elute therapeutic agents from the product coating and may provide extended release of the therapeutic agents over time. |
